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Choosing Between Xeomin and Jeuveau
If you want smoother skin and natural results, the decision doesn’t have to be confusing.
At Express Med Spa, guests often ask which injectable—Xeomin® or Jeuveau®—gives the best balance of smoothness, longevity, and natural movement.
Here’s a straightforward guide from our licensed aesthetic injectors so you can make an informed choice without hype or jargon.


Quick Comparison Chart: Xeomin vs Jeuveau
| Feature | Xeomin | Jeuveau |
|---|---|---|
| FDA Approved For | Frown lines between brows | Frown lines between brows |
| Main Ingredient | Botulinum toxin type A (incobotulinumA) | Botulinum toxin type A (prabotulinumA) |
| Formulation | “Naked” botulinum (no added proteins) | Filtered botulinum with stabilizers |
| Nickname | “Smart Toxin” | “NewTox” |
| Best For | Sensitive skin or resistance to other toxins | Fast, smooth forehead results |
| Duration | 3 – 4 months | 3 – 4 months |
| Downtime | Minimal | Minimal |
What Is Xeomin®?
Xeomin® is a purified neuromodulator used to relax the facial muscles that cause expression lines—especially the “11” lines between your brows.
Its standout feature is a protein-free formulation, meaning fewer additives your body can react to.
That makes Xeomin an excellent choice if you’ve noticed reduced results from Botox® or Dysport® over time, or if you have sensitive skin.
In clinical studies (Carruthers et al., Dermatologic Surgery, 2014), Xeomin performed as effectively as Botox® for glabellar lines while reducing the risk of antibody resistance.
A peer-reviewed study published in Dermatologic Surgery found that Xeomin performs as effectively as Botox in treating glabellar lines — while minimizing the risk of antibody resistance.
How Xeomin Works
Xeomin blocks nerve signals that cause repetitive muscle movement.
Once those muscles rest, the overlying skin smooths and fine lines fade.
Visible results: 3 – 4 days after treatment
Full results: within 2 weeks
Longevity: about 3 – 4 months
“We love Xeomin for clients who’ve had Botox or Dysport before but aren’t getting the same lift. Its clean formula delivers consistent, natural results,” says Karlene, Licensed Aesthetic Injector at Express Med Spa.
Xeomin Benefits
- Clean, additive-free “naked” formulation
- Lower risk of tolerance or resistance
- Gentle for sensitive skin or allergies
- Natural movement — no frozen look
- Ideal for long-term maintenance
Common Side Effects: Mild redness, pinpoint swelling, or slight bruising that fades quickly.
A licensed injector maps facial anatomy precisely to avoid unwanted effects—every treatment is customized, never overdone.


Where Xeomin Works Best
- Frown lines (between brows)
- Forehead wrinkles
- Crow’s feet (outer eye area)
- Chin dimpling
- Jawline slimming (off-label)
Xeomin Pricing at Express Med Spa
Xeomin typically ranges $10 – $14 per unit, depending on location and area treated.
| Area | Typical Units | Estimated Cost |
|---|---|---|
| Frown lines | ~20 units | $200 – $280 |
| Forehead | 10 – 15 units | $100 – $210 |
| Crow’s feet | 12 – 24 units | $120 – $336 |
💡 Tip: Ask about package or membership pricing for regular maintenance—patients who return every 3–4 months see smoother, more consistent results year-round.
What Is Jeuveau® (“NewTox”)?
Jeuveau® is another modern wrinkle relaxer containing botulinum toxin type A, FDA-approved for frown lines.
It’s nicknamed “NewTox” for its sleek formulation and smooth spread—especially popular for forehead lines and between-brow creases.
How Jeuveau Works
Jeuveau blocks the same nerve-to-muscle signals as Xeomin but is filtered differently, using a proprietary Hi-Pure™ technology.
Many clients notice slightly quicker smoothing on the forehead—often within 48 hours.
Ideal For: First-time users seeking quick, even forehead results with minimal downtime.
Jeuveau Benefits
- Fast onset (2 – 3 days for many patients)
- Smooth, even diffusion on forehead and frown lines
- Comfortable treatments with micro-injections
- Natural-looking softness without stiffness
Side Effects: Similar to Xeomin—temporary redness or mild tenderness at injection sites, resolving within hours.
Xeomin vs Jeuveau – Which Lasts Longer?
Both last about 3 to 4 months, though longevity depends on muscle strength, dosage, and consistency of treatment.
Patients who maintain a steady schedule often see smoother results for longer intervals over time.
Pro Injector Tip: Your facial muscles “train” to stay relaxed with repeated sessions, so fine lines return more slowly.
Cost Comparison
| Treatment | Average Cost per Unit | Typical Total (per area) |
|---|---|---|
| Xeomin | $10 – $14 | $200 – $350 |
| Jeuveau | $11 – $15 | $220 – $375 |
Both are comparable in price and value.
Xeomin’s purity appeals to long-term users, while Jeuveau’s smooth diffusion and quick onset make it a favorite for event-ready refreshes.
Which Is Right for You?
| If you value … | Choose … |
|---|---|
| A pure, protein-free formulation | Xeomin |
| Slightly faster results for forehead | Jeuveau |
| Lower risk of tolerance over time | Xeomin |
| Smoother diffusion for first-timers | Jeuveau |
| Sensitive skin or past allergies | Xeomin |
Both treatments deliver refreshed, natural-looking results when administered by a qualified clinician.
At Express Med Spa, every injectable is performed by licensed nurse practitioners and trained aesthetic injectors for safety, precision, and comfort.
If you’re nearby, explore our Xeomin treatments in Mount Greenwood, Chicago to see how this purified wrinkle relaxer delivers smooth, natural results with no downtime.
Expert Injector Insight
“Our goal is always subtlety. Most clients just want to look like themselves on a good day. Whether you choose Xeomin or Jeuveau, proper placement and dose are what make the difference.”
— Stefanie Drozd, APRN, Aesthetic Injector and Owner of Express Med Spa
Ready to Smooth Lines Your Way?
Both Xeomin and Jeuveau offer a path to refreshed, confident skin without the frozen look.
Our team will evaluate your goals, skin type, and treatment history to create a custom plan for you.
📍 Schedule Your Consultation at:
- Mount Greenwood (Chicago) – near Saint Xavier University
- Frankfort • La Grange • Shorewood
📞 Call / Text: (877) 363-3772
💻 Book Online: expressmedspas.com