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Letybo Wrinkle Injections 
at Express Med Spa

FDA-approved neurotoxin treatment to reduce frown lines with precision, purity, and natural-looking results. Now featuring globally trusted K-beauty innovation backed by 31 million treatments worldwide.
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Clinician administering Letybo botulinum toxin for frown lines at Express Med Spa in Frankfort, IL

What is Letybo 
and Why It’s Changing the Game in Aesthetic Injectables

Letybo (letibotulinumtoxinA-wlbg) is the newest FDA-approved botulinum toxin type A product for treating glabellar lines (commonly known as frown lines). With over 95% purity and consistent clinical outcomes, Letybo is ideal for patients who want smoother skin without a frozen look.
Now available at all Express Med Spa locations in Illinois, including Frankfort, Shorewood, Mount Greenwood (Chicago), and La Grange.

New: K-Beauty Meets American Aesthetics As the #1 neurotoxin in South Korea and a core part of K-beauty regimens, Letybo is formulated with precision and purity. It's trusted in over 65 countries and has been used in more than 31 million successful treatments worldwide.

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Injector preparing glabellar region for Letybo neurotoxin treatment at Express Med Spa in Frankfort, IL

How Letybo Works on Your Facial Muscles

Letybo works by blocking nerve signals that cause muscle contractions in the glabellar region. This effect softens deep frown lines over time. The neurotoxin targets SNAP25, a protein responsible for acetylcholine release, temporarily relaxing the corrugator and procerus muscles.
Faster Results: Some patients see visible softening in just 24 hours. 75% of users notice significant changes by Day 3, making Letybo one of the fastest-acting wrinkle relaxers available.
Results can last up to 16 weeks, depending on dosage and metabolism.

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FDA-approved Letybo vial displayed at Express Med Spa in Frankfort

FDA-Approved Protocol for Treating Frown Lines

Letybo was approved by the FDA in 2024 for the treatment of moderate to severe glabellar lines in adults.

Standard Dosing:Performed only by certified injectors at our clinician-owned aesthetic and wellness clinics.
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Happy Express Med Spa client after Letybo treatment for frown lines

Why Choose Letybo at Express Med Spa?

Patients across the Chicago suburbs are choosing Letybo because it offers:
  • A softer, more natural look compared to older neurotoxins
  • Lower incidence of side effects or “frozen face” feel
  • Highly purified formula—great for first-time patients or those switching from Botox or Xeomin
  • Administered by licensed RNs, NPs, and injectors in a serene, clinical setting

Clinically Proven in Head-to-Head Trials. In a 272-subject clinical trial, Letybo matched Botox in physician-assessed results and exceeded it in early photographic and patient satisfaction scores by Week 4. Subjective satisfaction at Week 8 was higher with Letybo (59.7%) than Botox (50.8%).

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Facial mapping before Letybo injections at Express Med Spa in Frankfort, IL for personalized wrinkle treatment

Is Letybo Right for You?

Letybo is not recommended for patients who are pregnant, breastfeeding, or have certain neuromuscular disorders.
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Med Spa Reviews 
Express Med Spa

“Definitely worth over 1/2 hr drive to visit Erica for my facials. Super attentive and takes her time with you. I've had a couple of facials done by her and each one makes my skin feel so much better! I'm planning on VI peel this fall and can't wait! Will keep you posted on results once done. Definitely recommend this Spa location!!!“


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Marisol Rodriguez
Google Review

“Tami and Erica E. were so unbelievably sweet and so helpful through the whole process! I will definitely be recommending my friends and family and going back to request them! Thank you both so much!”


Allison Cadena
Google Review

“Love Express Med Spa! Steph G is the best. Vicky at the front desk is a total sweetheart. I've been coming here for about 5 years now and never had a bad experience. Highly recommend!”


Jessica Davies
Google Review

“Stephanie is truly one of the best to ever do it, the before and after has been tremendous and I’ll be returning on the regular.”


Nate Stern
Google Review

“I LOVE EXPRESS MED SPA! The staff is amazing they are so warm and welcoming! I had terrible acne while pregnant and the express med spa staff helped me get my confidence back and achieve all of my skin goals! Can’t wait to get more services in the future!”


Alexandra Milani
Google Review

“20/10! Most definitely recommend!! I met with Kristina for my very first facial ever and it was just an awesome experience. She explained to me everything she was doing while doing it. Made me feel very comfortable. We also talked about different skin types and what would help with certain skins she recommended certain facials and products that would help and my skin has improved so much because of her!! Very kind and outgoing.”


Nay Nay
Google Review

Letybo patient consultation at Express Med Spa with licensed injector in Frankfort, IL

Safety, Side Effects & Medical Considerations

Letybo is well tolerated when administered by licensed medical professionals.

Most common side effects:

Serious risks (rare): In global clinical trials, no serious adverse events or neutralizing antibodies were detected. Laboratory results and safety outcomes remained favorable across all evaluation periods.
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Side-by-side comparison of Letybo and Botox used for treating glabellar lines and forehead wrinkles

Letybo vs. Botox and Other Injectables: What’s the Difference?

Clinical Note: Letybo demonstrated equal or better early-stage outcomes than Botox in photographic and patient satisfaction assessments at 4 and 8 weeks post-treatment
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Patient after Letybo wrinkle injection session at Express Med Spa in Shorewood, IL showing refreshed appearance

Your Letybo Experience: What to Expect

Before: You’ll have a personalized consultation with a licensed aesthetic injector. We assess facial anatomy and muscle movement to design a custom treatment plan.

During: 5 quick microinjections to the glabellar region. Entire process takes less than 10 minutes.

After: No downtime. Mild redness or swelling may occur. Results begin within 24–72 hours for most patients.

Duration: Lasts up to 16 weeks with peak results at 30 days.


Injector performing custom facial mapping before Letybo wrinkle treatment at Express Med Spa in La Grange, IL

Tailored for Every Face Shape and Skin Tone

Express Med Spa clinicians follow internationally published protocols for diverse facial aesthetics. We consider skin type, cultural preferences, and individual goals—particularly for patients of Asian or Middle Eastern descent seeking subtle softening, not volume loss.

Ethnically adaptive dosing strategies help personalize treatment for varied muscle mass and facial anatomy.

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Board-certified injectors specializing in Letybo 
Meet Your Letybo Certified Injectors in Frankfort & Beyond

  • Angelika Chrobak, RN - Advanced Letybo Injector (La Grange IL)
  • Stephanie Guenther  - Nurse Injector Specializing in Frown Lines (Frankfort)Stephanie Guenther
  • Tami Willett - Letybo & Neurotoxin Specialist (Mount Greenwood)
Angelika Chrobak RN administering Letybo injections in Shorewood IL
Stephanie Guenthe, RN – Licensed Esthetic Injector at Express Med Spa in Frankfort, IL, specializing in Letybo injections, facials, chemical peels, skincare, and anti-aging treatments.
Tami – Letybo and neurotoxin specialist at Express Med Spa in Mount Greenwood, Chicago, providing injectable wrinkle treatments and aesthetic services.
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Patient receiving Letybo treatment consultation with facial mapping at Express Med Spa Mount Greenwood, Chicago

FAQs About Letybo

Q: How soon will I see results from Letybo?

A: Some patients see visible changes within 24 hours. 75% report results by Day 3. Full smoothing appears by Week 2.

Q: What areas can Letybo treat?

A: Letybo is FDA-approved for glabellar lines. Off-label use should be discussed in-person.

Q: Where can I get Letybo near Frankfort or Shorewood?

A: Express Med Spa offers Letybo in Frankfort, Shorewood, Mount Greenwood (Chicago), and La Grange.

Q: Is Letybo a good alternative to Botox?

A: Yes. In clinical trials, Letybo matched or outperformed Botox in early patient satisfaction and photographic assessments.



Book your Letybo appointment at Express Med Spa for glowing, radiant skin with expert care

Book Your Letybo Treatment Today

Get smoother skin without compromising expression. Schedule your consultation and discover why Express Med Spa is a top-rated provider of Letybo in Frankfort, Shorewood, La Grange, and Mount Greenwood.
877-363-3772
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🧬 No pressure. Just personalized care that fits your goals.

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Five Star Reviews... and growing

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Stefanie Drozd, APRN
Founder & Nurse Practitioner
Let’s Talk About Your Skin Goals

Not sure if Letybo Injections are right for you?

You don’t have to guess what treatment is right for you. Book a complimentary consultation and let our licensed professionals help you choose the safest and most effective option. We will walk you through your options and help you decide what makes the most sense for your skin, goals, and budget.
Express Med Spa Team