What Is Letybo? The New Botox Alternative Everyone’s Talking About


Wrinkles don’t just appear overnight; they develop slowly, from years of smiling, frowning, or squinting. And while expressions are a beautiful part of who we are, sometimes we want a little help softening the lines they leave behind.
That’s where Letybo comes in, a new FDA-approved neurotoxin injectable that’s getting a lot of attention as a modern Botox alternative. But is it just another trend, or something worth considering for real results?
At Express Med Spa, we believe in giving you the full picture, clear, helpful, and based on real experience. In this guide, you’ll find everything you need to know about Letybo, how it works, what to expect, and expert tips to help you decide if it’s the right treatment for you.
Table of Contents
What Is Letybo?
Letybo is an FDA-approved botulinum toxin type A injectable used to relax facial muscles that cause fine lines and wrinkles. It targets the same areas as Botox, like forehead lines, glabellar lines associated with corrugator muscles, and crow’s feet, but it’s a newer product on the U.S. market, offering a modern alternative.
Developed by Hugel, Inc., a South Korean biotech company, Letybo has already been widely used in Europe, Canada, and Asia. It was officially approved for use in the U.S. in 2023, after undergoing rigorous clinical trials for safety and efficacy.
Think of Letybo as the newest neurotoxin on the block with impressive credentials, similar to Botox and Xeomin, but with its own strengths.
How Letybo Works
Letybo injections work by blocking the nerve signals that tell your facial muscles to contract. Less movement = fewer wrinkles. Simple as that.
Here’s how it works in practice:
- Every time you frown, smile, or raise your eyebrows, muscles tug on your skin.
- Over time, that movement creates creases.
- Letybo temporarily relaxes those muscles by targeting the nerve signals.
- Your skin smooths out as the muscles stay at rest.
The result is a more relaxed, refreshed version of you, not frozen, just softened.
Letibotulinumtoxina, the active ingredient in Letybo, is specifically formulated to treat the appearance of moderate to severe glabellar lines, especially the lines between the eyebrows, in dynamic facial areas.
Is Letybo Safe?


Yes, when administered by a trained provider, Letybo is considered very safe. It went through years of research, clinical studies, and was approved by the FDA before becoming available in the U.S.
At Express Med Spa, we take safety seriously. Our licensed injectors follow strict protocols and personalize every treatment to your needs.
- Key safety facts:
- Approved by the FDA in 2023
- Proven safe in double-blind clinical studies
- Comparable to Botox in outcomes and side effects of Letybo
If you’re generally healthy and not pregnant or nursing, Letybo may be a great option for you. However, it should not be used in individuals with hypersensitivity to any botulinum toxin.
Benefits of Letybo
So why are people switching to Letybo?
Here are the most talked-about benefits:
- Smooths expression lines without surgery
- Quick appointments (typically under 30 minutes)
- Minimal downtime
- Natural-looking results
- FDA-approved and globally trusted
- Competitive pricing compared to Botox
Many clients tell us they feel more confident just days after treatment. The results are subtle but impactful—you still look like you, just more rested and polished.
Possible Side Effects
Side effects of Letybo are usually mild and temporary. But knowing what to expect helps you feel confident and prepared.
Most common side effects:
- Redness or swelling at the injection site
- Mild bruising
- Temporary headaches
- Slight muscle tightness
Rare but more serious effects:
- Eyelid drooping (ptosis)
- Flu-like symptoms
- Muscle weakness near injection area
In very rare cases, Letybo may cause serious side effects, including symptoms consistent with botulinum toxin spread, such as trouble swallowing, speaking, or breathing.
To lower your risk, choose a qualified injector and follow all pre- and post-treatment care instructions.
Also, each injection is carefully measured using potency units of Letybo, ensuring accurate dosing for safe and effective results.
Safety Tips Before Getting Letybo
Before your treatment, there are a few smart steps you can take to get the best results and minimize risks:
- Pick a licensed medical professional. This isn’t something to DIY or get on a discount deal.
- Skip blood thinners like ibuprofen, aspirin, and fish oil a couple of days before treatment to help reduce bruising.
- Tell your provider about any health issues, allergies, or medications. Transparency ensures safety.
- Don’t plan this the day before a big event. Give your skin a few days to settle.
At Express Med Spa, we walk you through every step to make sure you feel fully informed and comfortable.
What to Expect During the Procedure
If it’s your first time, here’s what the Letybo experience looks like:
- Consultation – We map your face and talk through your goals.
- Prep – The area is cleaned and optionally numbed.
- Injection – Tiny needles deliver precise doses of Letybo to targeted muscles.
- Wrap-Up – You’ll get easy aftercare instructions and can usually return to your day.
Treatment time: Around 10–20 minutes
Results appear: Within 3 to 7 days
How long it lasts: 3 to 4 months on average
Want your results to last longer? Staying consistent with your treatments helps “train” your muscles to stay relaxed.
FAQs
Is Letybo better than Botox?
Letybo and Botox are both botulinum toxin type A injectables used to reduce wrinkles and fine lines—but which is better depends on your goals, skin type, and provider expertise.
Is Letybo approved in the US?
In December 2023, the U.S. Food and Drug Administration granted FDA approval to Letybo (developed by Hugel, Inc., a South Korean biopharmaceutical company) for temporary improvement of moderate to severe glabellar lines (frown lines) in adults.
How long does Letybo last?
Letybo typically lasts 3 to 4 months, aligning closely with other botulinum toxin type A products like Botox, Dysport, and Jeuveau.
Still Battling Fine Lines? Why Letybo Might Be the Refresh Your Skin’s Been Waiting For
Letybo is a safe, FDA-approved Botox alternative that takes only about 30 minutes to administer. Visible results typically appear within a few days, giving you smoother, more refreshed skin without the need for surgery or long recovery times. Whether you’re new to injectables or considering a switch, it’s worth exploring.
At Express Med Spa La Grange and in other branches, we don’t just inject—we educate, guide, and tailor each treatment to your unique beauty goals. Our team is here to help you feel confident in every decision you make about your skin.
Ready to try Letybo? Book your consultation with Express Med Spa today and let’s talk about how we can help you glow—naturally.
Not ready to commit? That’s exactly why we offer free consults.
🧬 No pressure. Just personalized care that fits your goals.


You don’t have to guess what treatment is right for you. Book a complimentary consultation and let our licensed professionals help you choose the safest and most effective option. We will walk you through your options and help you decide what makes the most sense for your skin, goals, and budget.Express Med Spa Team
Not ready to commit? That’s exactly why we offer free consults.
🧬 No pressure. Just personalized care that fits your goals.