Both Xeomin and Botox are FDA-approved neurotoxins used to reduce facial wrinkles. They work by relaxing facial muscles to smooth out lines, especially in areas like the forehead, around the eyes (crow’s feet), and between the eyebrows (glabellar lines).
While they function similarly, there are key differences in formulation, onset, longevity, and even cost. Understanding these distinctions will help you choose the right wrinkle treatment for your unique needs.
Table of Contents
How Do Xeomin and Botox Treat Wrinkles?
Both injectables use a purified form of botulinum toxin type A, which temporarily blocks signals between nerves and muscles. This muscle relaxation results in visibly smoother skin.
The treatment process involves injecting small units of either Xeomin or Botox into targeted muscles. Within days, muscle activity decreases, leading to a reduction in wrinkles.
What Are the Similarities and Differences Between Xeomin and Botox Cosmetic?
| Feature | Xeomin | Botox |
| Active Ingredient | Botulinum toxin type A | Botulinum toxin type A |
| Formulation | “Naked” neurotoxin (no additives) | Includes protective proteins |
| Onset of Results | 3-4 days | 3-5 days |
| Duration of Effects | ~3-4 months | ~3-4 months |
| Storage | No refrigeration needed | Must be refrigerated |
| Risk of Allergic Reaction | Lower | Slightly higher due to proteins |
What is Xeomin?
Xeomin (incobotulinumtoxinA) is a newer-generation wrinkle relaxer. Unlike Botox, Xeomin contains only the active neurotoxin—no added proteins or preservatives. This “naked” formulation reduces the risk of resistance and allergic reaction, making it ideal for those who have sensitivities or want a more minimalist option.
At Express Med Spa Frankfort, many of our clients who have experienced Botox resistance see improved results with Xeomin treatment.
What is Botox?
Botox (onabotulinumtoxinA) is the original brand-name botulinum toxin. It has been extensively studied and used for decades in both medical and cosmetic settings. Its reputation is built on reliability, predictability, and effectiveness.
Botox includes protective proteins that help stabilize the molecule, though in rare cases, these may trigger immune responses in sensitive individuals.
How They’re Made
- Xeomin is purified to remove all accessory proteins, leaving only the active neurotoxin.
- Botox includes complexing proteins, which can increase the chance of antibody formation over time, potentially reducing its effectiveness for some long-term users.
What They Treat
Both Xeomin and Botox are approved to treat:
- Frown lines (glabellar lines)
- Crow’s feet
- Forehead lines
- Neck bands
Botox is also approved for medical conditions like migraines, excessive sweating, and muscle spasms. Xeomin, while primarily cosmetic, is FDA-approved for some medical indications like cervical dystonia.
Benefits of Xeomin
- Cleaner formula: No additives or proteins, reducing risk of allergic reactions
- May be more effective long-term for those who develop resistance to Botox
- No refrigeration required: Easier storage for clinics
- More natural appearance in some users due to its targeted spread
Benefits of Botox
- Highly predictable: Decades of use with consistent results
- Wider range of FDA-approved uses
- Trusted by providers worldwide
- Great for first-time users who want proven results
Length of Effects: Which Lasts Longer?
Both Xeomin and Botox typically last 3 to 4 months, but this can vary based on factors like dosage, treatment area, metabolism, and individual muscle activity.
Some clients report slightly longer results with Xeomin, especially after multiple sessions. However, Botox is known for its predictable, even wear-off.
Faster Results: Which Works Quicker?
- Xeomin: Results may appear as early as 3 days post-injection.
- Botox: Usually takes 3 to 5 days, with full effects at around 7 days.
At Express Med Spas, we typically advise clients to wait up to 14 days to see the full effect, regardless of which product they choose.
May Cause Fewer Allergic Reactions
Since Xeomin contains only the active neurotoxin, it may reduce the risk of allergic reactions and antibody formation. This makes it a preferred option for clients with sensitivities or those who have stopped responding to Botox.
Possible Side Effects
Common side effects for both treatments include:
- Mild swelling or redness at the injection site
- Temporary headache
- Drooping eyelid or eyebrow (rare)
- Flu-like symptoms (very rare)
Side effects are generally mild and temporary. Choosing an experienced injector like those at Express Med Spas significantly reduces the risk of complications.
Which Is Better?
There is no one-size-fits-all answer. Xeomin vs Botox depends on your skin type, medical history, goals, and preferences.
Choose Xeomin if:
- You’ve developed resistance to Botox
- You prefer a cleaner, additive-free formulation
- You want to reduce the risk of allergies
Choose Botox if:
- You’re a first-time user
- You want tried-and-true predictability
- You’ve had great results with Botox before
At Express Med Spas, we offer personalized consultations to help you decide which wrinkle treatment fits you best.
Pregnancy and Breastfeeding
Neither Xeomin nor Botox is recommended for use during pregnancy or breastfeeding. There is limited research on safety in these conditions, so it’s best to delay treatment until after pregnancy and lactation.
Which Injection Costs More: Xeomin or Botox?
Cost per unit:
- Xeomin: $10 to $14
- Botox: $12 to $20
Total treatment cost varies depending on the number of units used. Xeomin is often slightly more affordable.
At Express Med Spas, we provide transparent pricing and customize your treatment plan to meet your budget and goals.
Can You Use Xeomin and Botox Together?
Yes, some providers use both products in different areas of the face. For example, Xeomin may be used for frown lines, while Botox is used for crow’s feet.
However, this requires advanced planning and experienced injectors. Express Med Spas ensures safe, effective protocols when combining treatments.
FAQs
Which is more affordable in price Xeomin vs Botox?
Xeomin is typically slightly cheaper per unit, but both are effective. Total cost depends on the area treated and units used.
Which lasts longer Xeomin or Botox?
On average, both last 3 to 4 months. Some patients report longer effects with Xeomin over time.
Is Xeomin as good as Botox?
Yes, Xeomin is equally effective for most cosmetic applications. The choice depends on personal goals and medical history.
Is 20 units of Xeomin the same as 20 units of Botox?
Yes. Unit potency is considered equal, so 20 units of Xeomin is roughly equivalent to 20 units of Botox.
Is Xeomin more natural looking?
Some patients say Xeomin gives a softer, more natural look due to its cleaner spread, but results vary based on injection technique.
Personalized Wrinkle Treatments Start Here
When comparing Xeomin vs Botox, it’s not about which is better overall, but which is better for you. Both are safe, effective wrinkle treatments that can help you look refreshed and confident.
At Express Med Spa Frankfort, our experts guide you through each option, helping you feel informed and empowered in your skin journey. Ready to smooth out lines and rediscover your glow?
Book a free consultation today and find out which wrinkle treatment is right for you.
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Not ready to commit?
That’s exactly why we offer free consults.
🧬 No pressure. Just personalized care that fits your goals.
Stefanie Drozd, APRN
Founder & Nurse Practitioner
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You don’t have to guess what treatment is right for you. Book a complimentary consultation and let our licensed professionals help you choose the safest and most effective option. We will walk you through your options and help you decide what makes the most sense for your skin, goals, and budget.Express Med Spa Team
