Xeomin vs Letybo: Which Should You Choose?

Wrinkle treatments have evolved far beyond Botox®. Two names making headlines are Xeomin and Letybo. Both smooth expression lines and rejuvenate the face, but their formulations and performance differ slightly.

Understanding how they compare helps you make an informed decision about which injectable best fits your goals and lifestyle. At Express Med Spa, our clients often ask about these options. The goal isn’t just to soften wrinkles, it’s to choose the product that aligns with your preferences, comfort, and long-term skincare strategy.

What Is the Difference Between Xeomin and Letybo?

Both Xeomin and Letybo contain botulinum toxin type A, the same active ingredient found in Botox and Dysport, but they differ in formulation.

• Xeomin is known as the “naked” neurotoxin. It’s purified to remove accessory proteins, leaving only the active ingredient.
• Letybo is more similar to Botox in structure and contains stabilizing proteins to help maintain consistency and dosing.

That single difference in formulation can affect how your body responds, how long results last, and whether you develop resistance over time.

To learn more about how botulinum toxin products work in aesthetic medicine, visit this clinical review from the National Center for Biotechnology Information

Xeomin vs Letybo: Side-by-Side Comparison

Formulation: Purity vs Stability

• Xeomin: The absence of accessory proteins makes Xeomin less likely to trigger antibody resistance. This is especially beneficial for long-term users who may have noticed reduced effectiveness with other neurotoxins like Botox or Dysport.
• Letybo: The added proteins give structure and may help results last longer for some individuals. Its advanced purification process promotes consistent dosing and smooth application.

In short: Xeomin offers reliability for experienced users, while Letybo appeals to first-time clients seeking Botox-like results with the potential for extended longevity.

Common Treatment Areas

Both injectables are FDA-approved for glabellar frown lines, but skilled injectors also use them off-label for:

• Forehead lines
• Crow’s feet around the eyes
• Bunny lines across the nose
• Lip flips and gummy smile correction
• Chin dimpling
• Jawline contouring or TMJ tension relief

At Express Med Spa, every treatment plan is customized based on facial anatomy and desired results. Precision in placement and dosage ensures natural, balanced outcomes. Learn more about Letybo wrinkle treatments offered at our medical spa in Frankfort and see how this injectable can help you achieve smooth, natural results.

Benefits of Xeomin and Letybo

Xeomin Advantages:

• Pure formulation reduces risk of antibody resistance
• Delivers smooth, natural movement
• Starts working within 3-4 days
• Supported by over a decade of FDA safety data

Letybo Advantages:

• Stable protein structure for consistency
• May last 4-6 months, slightly longer than some Botox treatments
• Provides refreshed, natural results
• Can be more cost-effective

Bottom line:
Xeomin offers long-term reliability, while Letybo provides a newer option with potentially extended duration at a similar price.

Side Effects and Safety

Both Xeomin and Letybo are considered safe when performed by licensed medical professionals. Common, mild side effects may include:

• Minor bruising or redness at the injection site
• Temporary tightness or mild headache
• Occasional eyelid drooping that resolves naturally within weeks

Serious side effects are rare but can include difficulty swallowing or breathing. If you experience dizziness, muscle weakness, or other unusual symptoms after treatment, seek medical help immediately.

Your injector’s experience is critical in minimizing risk and ensuring consistent, natural-looking results.

Duration of Results

• Xeomin: Typically lasts 3-4 months
• Letybo: Often lasts 4-6 months

Everyone’s body metabolizes neuromodulators differently. Those with faster metabolisms or strong facial muscles may notice results fade sooner. Your injector will help determine the ideal maintenance schedule based on your unique needs.

Pricing Overview

Pricing varies depending on the provider and the number of units used.

• Xeomin: Usually priced similarly to Botox Cosmetic
• Letybo: Sometimes offered at a slightly lower rate, since it’s newer in the U.S.

While price is one factor, choosing based on your body’s response and goals ensures better value long-term.

Which Injectable Is Right for You?

Choose Xeomin if:

• You’ve been using Botox or Dysport for years and worry about developing resistance
• You prefer a pure, protein-free formulation
• You value a product with a long-established safety record

Choose Letybo if:

• You’re new to wrinkle relaxers and want Botox-like results
• You’re looking for a longer-lasting treatment cycle
• You prefer a slightly lower-cost option with consistent results

Many clients try both over time to see which one aligns best with their goals. Your injector can track outcomes to help you make an informed decision.

FAQs About Xeomin vs Letybo

The Takeaway

Both Xeomin and Letybo are effective, FDA-approved treatments for facial wrinkles and expression lines.
Xeomin excels in purity and long-term reliability, while Letybo offers potentially longer results at a competitive price point.

At Express Med Spa, our experienced injectors create tailored treatment plans that enhance your natural beauty with precision and safety. Whether you’re exploring Xeomin, Letybo, or another wrinkle relaxer, we’ll help you achieve smooth, refreshed skin with results that feel authentically you.

Book your consultation and discover which injectable is best suited to your goals.